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Maps & Directions

Below are directions and a map to help you find the Avera Cancer Institute. If you have any questions concerning directions or parking, please call us at (605) 322-3000.

Avera Cancer Institute address:
1000 E. 21st Street
Sioux Falls, SD 57105

We are located on the Avera McKennan Hospital & University Health Center campus. The campus is on the west side of Cliff Ave between 10th St. and 26th St. Free valet parking is available at the Avera Cancer Institute entrance. Our valets are located just in side the entrance.

Driving Directions to Avera Cancer Institute

If you are traveling from the Northwest:

  • Take I-29 South to 12th Street, Exit 79
  • Take 12th Street east to Cliff Avernue
  • Turn right on Cliff Avenue and drive straight south
  • Turn right on 21st Street

If you are traveling from the Southwest:

  • Take I-29 North on I-229, Exit 75
  • Take I-229 to Cliff Avenue, Exit 4
  • Turn left on Cliff Avenue and drive straight north
  • Turn left on 21st Street

If you are traveling from the Northeast:

  • From I-90, take Cliff Avenue, Exit 339, and drive straight south, OR
  • Take I-229 South to 10th Street, Exit 6
  • Turn right on 10th Street and drive to Cliff Avenue
  • Turn left on Cliff Avenue and drive south
  • Turn right on 21st Street

If you are traveling from the Southeast:

  • Take 26th Street to Cliff Avenue
  • Turn right on Cliff Avenue and drive north
  • Turn left on 21st Street

Parking at Avera Cancer Institute

Patient parking is available in the lot directly in front of the building. You can access this lot from 21st Street. If this lot is full, there is parking available on the streets adjacent to the building. Avera McKennan also has two parking ramps(North Parking Ramp and South Parking Ramp) on campus connected by skywalk to the hospital, Avera Cancer Institute, and other campus buildings.